Where to give?

I'm trying decide how to divvy up my charitable contributions this year, and in addition to the usual suspects (The Ocean Conservancy, Defenders of Wildlife, Rainforest Alliance, and maybe Marine Mammal again), I'm thinking of an actual human -- related charity: Americans for the Arts.

Or I could just give it all to Earthshare and let them sort it out. But that's an extra level of bureaucracy, and their radio ads featuring Harrison Ford in a dead monotone are kind of creepy.